2of2: Difference between revisions
New page: left|200px<br /> <applet load="2of2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2of2, resolution 2.00Å" /> '''crystal structure o... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2of2.gif|left|200px]]<br /> | [[Image:2of2.gif|left|200px]]<br /><applet load="2of2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2of2" size=" | |||
caption="2of2, resolution 2.00Å" /> | caption="2of2, resolution 2.00Å" /> | ||
'''crystal structure of furanopyrimidine 8 bound to lck'''<br /> | '''crystal structure of furanopyrimidine 8 bound to lck'''<br /> | ||
| Line 6: | Line 5: | ||
==Overview== | ==Overview== | ||
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties. | 2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties. | ||
==About this Structure== | ==About this Structure== | ||
2OF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 547 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http:// | 2OF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=547:'>547</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF2 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 23: | Line 19: | ||
[[Category: lck]] | [[Category: lck]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:32:13 2008'' | ||
