2gg3: Difference between revisions
New page: left|200px<br /><applet load="2gg3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gg3, resolution 1.450Å" /> '''Novel bacterial met... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2gg3.gif|left|200px]]<br /><applet load="2gg3" size=" | [[Image:2gg3.gif|left|200px]]<br /><applet load="2gg3" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2gg3, resolution 1.450Å" /> | caption="2gg3, resolution 1.450Å" /> | ||
'''Novel bacterial methionine aminopeptidase inhibitors'''<br /> | '''Novel bacterial methionine aminopeptidase inhibitors'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
2GG3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CO, NA and U13 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http:// | 2GG3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=U13:'>U13</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GG3 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 26: | Line 26: | ||
[[Category: pita-bread fold]] | [[Category: pita-bread fold]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:30:10 2008'' | ||
Revision as of 16:30, 23 January 2008
|
Novel bacterial methionine aminopeptidase inhibitors
OverviewOverview
In this article we describe the application of structural biology methods, to the discovery of novel potent inhibitors of methionine aminopeptidases., These enzymes are employed by the cells to cleave the N-terminal, methionine from nascent peptides and proteins. As this is one of the, critical steps in protein maturation, it is very likely that inhibitors of, these enzymes may prove useful as novel antibacterial agents. Involvement, of crystallography at the very early stages of the inhibitor design, process resulted in serendipitous discovery of a new inhibitor class, the, pyrazole-diamines. Atomic-resolution structures of several inhibitors, bound to the enzyme illuminate a new mode of inhibitor binding.
About this StructureAbout this Structure
2GG3 is a Single protein structure of sequence from Escherichia coli with , and as ligands. Active as Methionyl aminopeptidase, with EC number 3.4.11.18 Full crystallographic information is available from OCA.
ReferenceReference
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors., Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A, Proteins. 2007 Feb 15;66(3):538-46. PMID:17120228
Page seeded by OCA on Wed Jan 23 15:30:10 2008