2j0m: Difference between revisions
New page: left|200px<br /> <applet load="2j0m" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j0m, resolution 2.80Å" /> '''CRYSTAL STRUCTURE A... |
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==About this Structure== | ==About this Structure== | ||
2J0M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with 4ST as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0M OCA]]. | 2J0M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with 4ST as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0M OCA]]. | ||
==Reference== | ==Reference== | ||
Structural basis for the autoinhibition of focal adhesion kinase., Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ, Cell. 2007 Jun 15;129(6):1177-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17574028 17574028] | Structural basis for the autoinhibition of focal adhesion kinase., Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ, Cell. 2007 Jun 15;129(6):1177-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17574028 17574028] | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cai, X.]] | [[Category: Cai, X.]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:55:29 2007'' | ||
Revision as of 12:50, 30 October 2007
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CRYSTAL STRUCTURE A TWO-CHAIN COMPLEX BETWEEN THE FERM AND KINASE DOMAINS OF FOCAL ADHESION KINASE.
OverviewOverview
Appropriate tyrosine kinase signaling depends on coordinated sequential, coupling of protein-protein interactions with catalytic activation. Focal, adhesion kinase (FAK) integrates signals from integrin and growth factor, receptors to regulate cellular responses including cell adhesion, migration, and survival. Here, we describe crystal structures representing, both autoinhibited and active states of FAK. The inactive structure, reveals a mechanism of inhibition in which the N-terminal FERM domain, directly binds the kinase domain, blocking access to the catalytic cleft, and protecting the FAK activation loop from Src phosphorylation., Additionally, the FERM domain sequesters the Tyr397 autophosphorylation, and Src recruitment site, which lies in the linker connecting the FERM and, kinase ... [(full description)]
About this StructureAbout this Structure
2J0M is a [Single protein] structure of sequence from [Gallus gallus] with 4ST as [ligand]. Active as [Non-specific protein-tyrosine kinase], with EC number [2.7.10.2]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis for the autoinhibition of focal adhesion kinase., Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ, Cell. 2007 Jun 15;129(6):1177-87. PMID:17574028
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