3d0e: Difference between revisions

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{{Seed}}
[[Image:3d0e.png|left|200px]]
[[Image:3d0e.png|left|200px]]


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{{ABSTRACT_PUBMED_18800763}}
{{ABSTRACT_PUBMED_18800763}}
==Disease==
Known disease associated with this structure: Diabetes mellitus, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164731 164731]]


==About this Structure==
==About this Structure==
3D0E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0E OCA].  
[[3d0e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0E OCA].  


==Reference==
==Reference==
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[[Category: Concha, N O.]]
[[Category: Concha, N O.]]
[[Category: Smallwood, A.]]
[[Category: Smallwood, A.]]
[[Category: Akt2]]
[[Category: Atp-binding]]
[[Category: Human]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:38:46 2009''

Revision as of 13:01, 21 April 2011

File:3d0e.png

Template:STRUCTURE 3d0e

Crystal structure of human Akt2 in complex with GSK690693Crystal structure of human Akt2 in complex with GSK690693

Template:ABSTRACT PUBMED 18800763

About this StructureAbout this Structure

3d0e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]o xy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem. 2008 Sep 25;51(18):5663-79. PMID:18800763 doi:10.1021/jm8004527

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