2hc4: Difference between revisions
New page: left|200px<br /> <applet load="2hc4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hc4, resolution 2.2Å" /> '''Crystal structure of... |
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[[Image:2hc4. | [[Image:2hc4.jpg|left|200px]]<br /><applet load="2hc4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="2hc4, resolution 2.2Å" /> | caption="2hc4, resolution 2.2Å" /> | ||
'''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''<br /> | '''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2HC4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with VDX as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2HC4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with <scene name='pdbligand=VDX:'>VDX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC4 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: alpha helical sandwich]] | [[Category: alpha helical sandwich]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:27:00 2008'' | ||
Revision as of 16:27, 23 January 2008
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Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol
OverviewOverview
The crystal structure of the ligand binding domain (LBD) of the wild-type, Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist, ligand with two identical side chains branching at carbon 20 reveals a, ligand-dependent structural rearrangement of the ligand binding pocket, (LBP). The rotation of a Leu side chain opens the access to a channel that, can accommodate the second side chain of the ligand. The 25% increase of, the LBP's volume does not alter the essential agonist features of VDR. The, possibility to adapt the LBP to novel ligands with different chemistry, and/or structure opens new perspectives in the design of more specifically, targeted ligands.
About this StructureAbout this Structure
2HC4 is a Protein complex structure of sequences from Danio rerio with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092
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