Sandbox Reserved 192: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Lauren Garnett, R. Jeremy Johnson, Liz Ellis

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 =='''History'''==
-RNase A has been used as a foundation enzyme for study. The 1972 Nobel Prize in Chemistry was awarded to three researchers for their work with RNase A. Christian Anfinsen, as previously mentioned, was honored for his lecture, "Studies on the principles that govern the folding of protein chains."   Stanford Moore and William H. Stein were honored for their work on "The Chemical Structures of Pancreatic Ribonuclease and Deoxyribonuclease." The 1984 Nobel Prize in Chemistry was awarded to Robert Bruce Merrifield for his work on "Solid-Phase Synthesis" using RNase A. By mutating the residues of RNase A using site-directed mutagenesis [http://en.wikipedia.org/wiki/Site-directed_mutagenesis], the effects of these mutations were more visibly analyzed with advances in analytical chemistry instrumentation and techniques. RNase A was the first enzyme and third protein for which its amino acid sequence was correctly determined and the third enzyme and fourth protein whose three-dimensional structure was determined by X-ray diffraction analysis. NMR spectroscopy [http://en.wikipedia.org/wiki/NMR_spectroscopy] and Fourier transform infrared (FTIR) spectroscopy [http://en.wikipedia.org/wiki/Fourier_transform_infrared_spectroscopy] also were used with RNase A to describe protein structure and protein folding.
+RNase A has been used as a foundation enzyme for study. The 1972 Nobel Prize in Chemistry was awarded to three researchers for their work with RNase A on the folding of chains in RNase A and the stability of RNase A. By mutating the residues of RNase A using site-directed mutagenesis [http://en.wikipedia.org/wiki/Site-directed_mutagenesis], the effects of these mutations were more visibly analyzed with advances in analytical chemistry instrumentation and techniques. RNase A was the first enzyme and third protein for which its amino acid sequence was correctly determined and the third enzyme and fourth protein whose three-dimensional structure was determined by X-ray diffraction analysis. NMR spectroscopy [http://en.wikipedia.org/wiki/NMR_spectroscopy] and Fourier transform infrared (FTIR) spectroscopy [http://en.wikipedia.org/wiki/Fourier_transform_infrared_spectroscopy] also were used with RNase A to describe protein structure and protein folding.
 =='''Medical Implications'''==