Intrinsically Disordered Protein: Difference between revisions
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Many [[X-ray crystallography|crystallographic]] structures have missing loops -- that is, ranges of amino acids with no [[atomic coordinate file|atomic coordinates]] in the model. These "gaps" in the model are often thought to be artifacts of inadvertant disorder in the crystal. In some cases, these gaps may be alerting us to the presence of intrinsically disordered loops in an otherwise folded protein. Such gaps are the basis for the [[#Protein disorder predictors|DISOPRED2 disorder prediction server]]. [[FirstGlance in Jmol]] offers [[Temperature_value#Missing_Residues|one method for locating and visualizaing such gaps]]. | Many [[X-ray crystallography|crystallographic]] structures have missing loops -- that is, ranges of amino acids with no [[atomic coordinate file|atomic coordinates]] in the model. These "gaps" in the model are often thought to be artifacts of inadvertant disorder in the crystal. In some cases, these gaps may be alerting us to the presence of intrinsically disordered loops in an otherwise folded protein. Such gaps are the basis for the [[#Protein disorder predictors|DISOPRED2 disorder prediction server]]. [[FirstGlance in Jmol]] offers [[Temperature_value#Missing_Residues|one method for locating and visualizaing such gaps]]. | ||
Despite the existence of compelling evidence for IUPs and intrinsically disordered loops for over a decade, many current textbooks of biochemistry and even some monographs on protein structure fail to mention intrinsic disorder and its importance for protein function<ref>PMID: 18831774</ref><ref>Book review: <i>Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M.</i>, reviewed by E. Martz. <i>Biochem. Mol. Biol. Educ.</i> 33:144-5 (2006). DOI: 10.1002/bmb.2005.494033022442</ref> | Despite the existence of compelling evidence for IUPs and intrinsically disordered loops for over a decade, many current textbooks of biochemistry and even some monographs on protein structure fail to mention intrinsic disorder and its importance for protein function<ref>PMID: 18831774</ref><ref>Book review: <i>Introduction to protein science—architecture, function, and genomics: Lesk, Arthur M.</i>, reviewed by E. Martz. <i>Biochem. Mol. Biol. Educ.</i> 33:144-5 (2006). DOI: 10.1002/bmb.2005.494033022442</ref>. In 2011, Chouard provided a readable and informative overview of IUPs and how some of them function<ref>PMID: 21390105</ref>. | ||
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