Sandbox Reserved 313: Difference between revisions
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{{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}} | {{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}} | ||
=Introduction= | =Introduction= | ||
'''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to [[ceramide]] and [[phosphocholine]]. This enzyme also has hemolytic activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>. SMase is a member of the DNA-I superfamily involved inhydrolytic cleavage metabolism reactions. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [http://en.wikipedia.org/wiki/Signal_transduction] | '''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to [[ceramide]] and [[phosphocholine]]. This enzyme also has hemolytic activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>. SMase is a member of the DNA-I superfamily involved inhydrolytic cleavage metabolism reactions. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [http://en.wikipedia.org/wiki/Signal_transduction signal transduction pathway] which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586 </ref>. | ||
==Types of SMase<ref name="gp3">PMID: 12401200 </ref>:== | ==Types of SMase<ref name="gp3">PMID: 12401200 </ref>:== | ||