Sandbox Reserved 328: Difference between revisions
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[[Image:pathways.jpg]] | [[Image:pathways.jpg]] | ||
The mechanism currently proposed by Teng and Grubmeyer<ref name="mech"> PMID:10353848 </ref> has been supported by structural data, and begins with the extraction of one proton and one hydride from L-histidinol<ref name="1kar" />. | The mechanism currently proposed by Teng and Grubmeyer<ref name="mech"> PMID:10353848 </ref> has been supported by structural data, and begins with the extraction of one proton and one hydride from L-histidinol<ref name="1kar" />. Next, the reduced NADH leaves and is replaced by another NAD+. The last step is a repetition of the first step. His-327 abstracts a proton from the hydroxyl group, and the second NAD+ molecule is reduced by a hydride. This leads to the formation of l-histidine. | ||
==Other information== | ==Other information== | ||
=== | ===Gene Duplication=== | ||
Domains 1 and 2 show high similarity in their cores, in a structural way rather than having large amounts of residues in common<ref name="1kar" />. This is also evident in the presense of hydrophobic residues forming the core of the domains. | Domains 1 and 2 show high similarity in their cores, in a structural way rather than having large amounts of residues in common<ref name="1kar" />. This is also evident in the presense of hydrophobic residues forming the core of the domains. | ||
===Domain Swapping=== | ===Domain Swapping=== | ||