Sandbox Reserved 313: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Justine Doherty

@@ Line 6: / Line 6: @@
 {{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}}
 =Introduction=
-'''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to ceramide and phosphocholine.  This enzyme also has hemolytic activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>.  This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [[signal transduction pathway]] which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase  hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586  </ref>.
+'''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin (SM) to [[ceramide]] and [[phosphocholine]].  This enzyme also has hemolytic activity where red blood cells are ruptured and hemoglobin is released into the blood plasma. <ref name="gp">PMID: 16595670 </ref>.  This enzyme has become the object of renewed interest since the discovery of the sphingomyelin [[signal transduction pathway]] which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase  hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586  </ref>.
 ==Types of SMase<ref name="gp3">PMID: 12401200 </ref>:==