Sandbox Reserved 327: Difference between revisions
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=Introduction= | =Introduction= | ||
Translation is an essential process for both prokaryotes and eukaryotes to make various proteins from nucleic acid. It requires three different steps: initiation, elongation, and termination. Many proteins are needed in the initiation phase to form an initiation complex with the ribosome and promote the translation. In eukaryotes, these proteins are also known as eukaryotic initiation factors (eIF). The eIFs were first studied through the genetic analyzed of yeast ''Saccharomyces cerevisiae'' <ref name="elegans"/>. The initiation process is complex since it involves at least 12 eIFs containing more than 30 polypeptides , including eIF1, eIF2, eIF3, eIF4, and eIF5 <ref name="elegans"/>. | Translation is an essential process for both prokaryotes and eukaryotes to make various proteins from nucleic acid. It requires three different steps: initiation, elongation, and termination. Many proteins are needed in the initiation phase to form an initiation complex with the ribosome and promote the translation. In eukaryotes, these proteins are also known as eukaryotic initiation factors (eIF). The eIFs were first studied through the genetic analyzed of yeast ''Saccharomyces cerevisiae'' <ref name="elegans"/>. The initiation process is complex since it involves at least 12 eIFs containing more than 30 polypeptides , including eIF1, eIF2, eIF3, eIF4, and eIF5 <ref name="elegans"/>. | ||
=Structure= | |||
{{STRUCTURE_2ogh|PDB=2ogh|SCENE}} | {{STRUCTURE_2ogh|PDB=2ogh|SCENE}} | ||
eIF1 is a small protein (12 kDa) that is encode by ''sui1'' which is one of the component of multifactor complex (MFC) that plays an important role in regulating translation initiation <ref name="eIF1"/><ref name="asano"/>. eIF1 is a universal translation factor across organisms which make eIF1 homologs can be found in other eukayotes, archaea, and some bacteria <ref name="flet"/>. Yeast eIF1 contains a | eIF1 is a small protein (12 kDa) that is encode by ''sui1'' which is one of the component of multifactor complex (MFC) that plays an important role in regulating translation initiation <ref name="eIF1"/><ref name="asano"/>. eIF1 is a universal translation factor across organisms which make eIF1 homologs can be found in other eukayotes, archaea, and some bacteria <ref name="flet"/>. Yeast eIF1 contains a | ||
<scene name='Sandbox_Reserved_327/Ribbon_structure/1'>β-sheet with α helices</scene> | <scene name='Sandbox_Reserved_327/Ribbon_structure/1'>β-sheet with α helices</scene> | ||