Sandbox Reserved 327: Difference between revisions
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There are two | There are two | ||
<scene name='Sandbox_Reserved_327/Basic_eif1/3'>eIF1-eIF5 binding sites</scene>: at the NTT site of eIF1 and at a KH surface area, a specific region that rich in Lysine (K) and hydrophobic (H) residues <ref name="eIF1"/>. These bindings are different from the eIF1-ribosome binding site and are salt dependent, with high salt concentration would make the interaction weaker <ref name="eIF1"/>. The eIF1-NTT area is believed to play role in stimulating the MFC assembly by promoting the eIF5- eIF2β <ref name="eIF1"/>. The other binding site area (eIF1-KH) is believed to play role in the AUG start codon selection in translation initiation <ref name="eIF1"/>. | <scene name='Sandbox_Reserved_327/Basic_eif1/3'>eIF1-eIF5 binding sites</scene>: at the NTT site of eIF1 and at a KH surface area, a specific region that rich in Lysine (K) and hydrophobic (H) residues <ref name="eIF1"/>. These bindings are different from the eIF1-ribosome binding site and are salt dependent, with high salt concentration would make the interaction weaker <ref name="eIF1"/>. The eIF1-NTT area is believed to play role in stimulating the MFC assembly by promoting the eIF5- eIF2β <ref name="eIF1"/>. The other binding site area (eIF1-KH) is believed to play role in the AUG start codon selection in translation initiation <ref name="eIF1"/>. | ||
mutations on this site??? | |||
*altering the basic part of eIF1-KH | |||
*altering the hydrophobic residues of eIF1 | |||
=Function and Mechanism= | =Function and Mechanism= | ||
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==Multifactor Complex Assembly== | ==Multifactor Complex Assembly== | ||