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=S-Adenosylmethionine decarboxylase= | =S-Adenosylmethionine decarboxylase= | ||
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S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the polyamine biosynthetic pathway, forming the amine decarboxylated S-adenosylmethionine <ref name="primary">PMID: 11583147</ref><ref name="two">PMID: 9353291</ref> It also aids in the synthesis of spermine and spermidine <ref name="primary"/><ref name="three">PMID: 11583148</ref><ref name="four">PMID: 12600205</ref>. Spermine and spermidine are polyamines that are essential growth factors and critical in cell differentiation <ref name="four"/><ref name="five">PMID: 19527050</ref>. Their levels within cells are regulated by the amount of AdoMetDC available <ref name="four"/>. Thus, AdoMetDC is tightly regulated in mammalian cells <ref name="primary"/>. | S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the polyamine biosynthetic pathway, forming the amine decarboxylated S-adenosylmethionine <ref name="primary">PMID: 11583147</ref><ref name="two">PMID: 9353291</ref> It also aids in the synthesis of spermine and spermidine <ref name="primary"/><ref name="three">PMID: 11583148</ref><ref name="four">PMID: 12600205</ref>. Spermine and spermidine are polyamines that are essential growth factors and critical in cell differentiation <ref name="four"/><ref name="five">PMID: 19527050</ref>. Their levels within cells are regulated by the amount of AdoMetDC available <ref name="four"/>. Thus, AdoMetDC is tightly regulated in mammalian cells <ref name="primary"/>. | ||