Sandbox Reserved 327: Difference between revisions

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 ==eIF1-ribosome binding site==
-The eIF1 would bind to the small subunit (40S) of a ribosome, in its P-site region. This binding would affect the conformation of the 40S subunit and the position of mRNA and the start codon initiation  <ref name="lomakin"/>. Surprisingly, this binding site region is similar to the binding site of prokaryotic initiation factor IF3 to the ribosome, despite their unrelated structure <ref name="lomakin"/>.
+The eIF1 would bind to the ribosomal 40S, in its P-site region. This binding would affect the conformation of the 40S subunit and the position of mRNA and the start codon initiation  <ref name="lomakin"/>. Surprisingly, this binding site region is similar to the binding site of prokaryotic initiation factor IF3 to the ribosome, despite their unrelated structure <ref name="lomakin"/>.eIF1 would form a ternary complex (TC) with eIF2 bound with GTP and Met-tRNA<sub>i</sub><sup>Met</sup> and binds to the ribosomal 40S, forming a 43 complex <ref name="eIF1"/><ref name="cheung"/><ref name="lomakin"/>.
 ==eIF1-eIF5 binding sites==