Sandbox Reserved 344: Difference between revisions
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=Introduction= | =Introduction= | ||
PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg2+ concentration and is an important trigger for gram-negative bacteria such as Escherichia coli and Salmonella enterica to become virulent. PhoQ, located across the inner membrane, responds to low Mg2+ concentration by phosphorylating PhoP. Gene regulation and other two component systems respond to the phosphorylated PhoP. Gene regulation is achieved by increased affinity of the homodimer to the PhoP box, a tandem repeat promoter. The response is organism specific but generally involves survival in low Mg2+ environments and virulence. | PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg2+ concentration and is an important trigger for gram-negative bacteria such as Escherichia coli and Salmonella enterica to become virulent. PhoQ, located across the inner membrane, responds to low Mg2+ concentration by phosphorylating PhoP. Gene regulation and other two component systems respond to the phosphorylated PhoP. Gene regulation is achieved by increased affinity of the homodimer to the PhoP box, a tandem repeat promoter. The response is organism specific but generally involves survival in low Mg2+ environments and virulence. <ref name = "Bachh2007"> PMID:17545283</ref> | ||
=Structure= | =Structure= | ||