Sandbox Reserved 316: Difference between revisions
Eric Ginter (talk | contribs) No edit summary |
Eric Ginter (talk | contribs) No edit summary |
||
| Line 22: | Line 22: | ||
==Additional Information== | ==Additional Information== | ||
As simvastatin is an active pharmaceutical ingredient in the cholesterol-lowering drug Zocor®, its efficient synthesis from lovastatin, via LovD is intensely pursued <ref name="paper4">PMID:19875080</ref>. | As simvastatin is an active pharmaceutical ingredient in the cholesterol-lowering drug Zocor®, its efficient synthesis from lovastatin, via LovD is intensely pursued <ref name="paper4">PMID:19875080</ref>. | ||
| Line 28: | Line 27: | ||
17113998</ref>. The alpha-S-methylbutyrate side chain is synthesized by the lovastatin diketide synthase (LDKS) LovF and then transferred by LovD regioselectively to the C8 hydroxyl of MJA<ref name="paper3">PMID:18988191</ref>. | 17113998</ref>. The alpha-S-methylbutyrate side chain is synthesized by the lovastatin diketide synthase (LDKS) LovF and then transferred by LovD regioselectively to the C8 hydroxyl of MJA<ref name="paper3">PMID:18988191</ref>. | ||
Among enzyme that have known structures, EstB (cephalosporin esterase), is homologous to LovD: 26% sequence identity <ref name="paper6">PMID: | Among enzyme that have known structures, EstB <scene name='Sandbox_Reserved_316/Estb/1'>EstB</scene> (cephalosporin esterase), is homologous to LovD: 26% sequence identity <ref name="paper6">PMID: | ||
11847270</ref>. | 11847270</ref>. | ||
==References== | ==References== | ||
<references/> | <references/> | ||