Beta-2 Adrenergic Receptor: Difference between revisions

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David Canner, Wayne Decatur, Michal Harel, Dotan Shaniv, Joel L. Sussman, Alexander Berchansky

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 <StructureSection load='1dq8' size='490' side='right' caption='Solved Structures of a Beta 2-Adrenergic Receptor' scene=' ' >
-[[Image:B2ar Image.png|120px|left]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; [[Beta-2 Adrenergic Receptor]]'''s''' (B2ARs) are a type of G Protein-Coupled Receptor (GPCR). GPCRs are the largest family of integral membrane proteins in the human body with over 1000 unique Isoforms. B2AR is activated by hormone ligands like adrenaline (epinephrine) and noradrenaline and plays a critical role in cardiovascular and pulmonary physiology. Binding of adrenaline by B2AR causes a sympathetic nervous system response like the well-known “flight or flight response”, resulting in an increased heart rate, pupil dilation, rapid energy mobilization and diversion of blood to skeletal muscle. More precisely, upon binding a ligand, B2AR activates [[Adenylyl cyclase]] through interaction with B2ARs C-terminus. Adenylyl cyclase subsequently converts ATP into cAMP, which functions as a downstream signaling molecule activating effectors like cAMP-dependent protein kinases, resulting in various bodily responses.<ref name="Witter"/>
+[[Image:B2ar Image.png|250px|left]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; [[Beta-2 Adrenergic Receptor]]'''s''' (B2ARs) are a type of G Protein-Coupled Receptor (GPCR). GPCRs are the largest family of integral membrane proteins in the human body with over 1000 unique Isoforms. B2AR is activated by hormone ligands like adrenaline (epinephrine) and noradrenaline and plays a critical role in cardiovascular and pulmonary physiology. Binding of adrenaline by B2AR causes a sympathetic nervous system response like the well-known “flight or flight response”, resulting in an increased heart rate, pupil dilation, rapid energy mobilization and diversion of blood to skeletal muscle. More precisely, upon binding a ligand, B2AR activates [[Adenylyl cyclase]] through interaction with B2ARs C-terminus. Adenylyl cyclase subsequently converts ATP into cAMP, which functions as a downstream signaling molecule activating effectors like cAMP-dependent protein kinases, resulting in various bodily responses.<ref name="Witter"/>
 ====B2AR and Autism====