1e9p: Difference between revisions
New page: left|200px<br /> <applet load="1e9p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e9p, resolution 1.70Å" /> '''CRYSTAL STRUCTURE O... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1E9P is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CU and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.1.1 1.13.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E9P OCA]]. | 1E9P is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CU and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_1.13.11.1 Transferred entry: 1.13.11.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.1.1 1.13.1.1]]. Structure known Active Sites: CU1, CU2, CU3 and ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E9P OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Transferred entry: 1.13.11.1]] | |||
[[Category: Hasnain, S.S.]] | [[Category: Hasnain, S.S.]] | ||
[[Category: Hough, M.A.]] | [[Category: Hough, M.A.]] | ||
| Line 23: | Line 24: | ||
[[Category: superoxide]] | [[Category: superoxide]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:50:37 2007'' | ||
Revision as of 12:45, 30 October 2007
|
CRYSTAL STRUCTURE OF BOVINE CU, ZN SOD TO 1.7 ANGSTROM (3 OF 3)
OverviewOverview
The structure of the catalytic site in one subunit of bovine CuZn, superoxide dismutase is shown to be highly variable. A series of crystal, structures at approximately 1.7 A have been determined using data, collected from different crystals. Several conformations are observed for, the copper site from one of the subunits. These conformations lie between, those expected for the Cu(II) and Cu(I) forms of the enzyme and may, represent a slow positional rearrangement of the Cu site during the, crystallisation process due to the presence of a trace reductant in the, mother liquor. These states perhaps indicate some functionally relevant, structural steps that ultimately result in the breakage of the imidazolate, bridge between the two metal sites.This behaviour is not observed for the, second ... [(full description)]
About this StructureAbout this Structure
1E9P is a [Protein complex] structure of sequences from [Bos taurus] with CU and ZN as [ligands]. Active as [Transferred entry: 1.13.11.1], with EC number [1.13.1.1]. Structure known Active Sites: CU1, CU2, CU3 and ZNB. Full crystallographic information is available from [OCA].
ReferenceReference
Conformational variability of the Cu site in one subunit of bovine CuZn superoxide dismutase: the importance of mobility in the Glu119-Leu142 loop region for catalytic function., Hough MA, Strange RW, Hasnain SS, J Mol Biol. 2000 Nov 24;304(2):231-41. PMID:11080458
Page seeded by OCA on Tue Oct 30 11:50:37 2007