Sandbox Reserved 200: Difference between revisions

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OCA, Lexi Gehring, R. Jeremy Johnson, Jaime Prilusky

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 =Introduction=
 [[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]]
-Bovine pancreatic ribonuclease A [http://en.wikipedia.org/wiki/Ribonuclease_A (RNase A)] is an enzyme that catalyzes the hydrolysis of RNA through [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 acid-base catalysis].   RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 RNase A monomer].  Unlike the monomers, these oligomers are capable of catalyzing the hydrolysis of double stranded RNA (dsRNA).<ref name="tumor">PMID:12697760</ref>  The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >.  The 3D domain swapping has no impact on the formation of active sites.  These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer <ref name="liul"/>.  The oligomers of RNase A also show medical relevance when looking at antitumor drugs as well as the possible cause of Alzheimer's.
+Bovine pancreatic ribonuclease A [http://en.wikipedia.org/wiki/Ribonuclease_A (RNase A)] is an enzyme that catalyzes the hydrolysis of RNA through [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_193 acid-base catalysis].   RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [http://www.proteopedia.org/wiki/index.php/Sandbox_Reserved_192 RNase A monomer].  Unlike the monomers, these oligomers are capable of catalyzing the hydrolysis of double stranded RNA (dsRNA).<ref name="tumor">PMID:12697760</ref>  The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >.  The 3D domain swapping has no impact on the formation of active sites which is the same in the monomers and all oligomers.<ref name="liul"/>  The oligomers of RNase A also show medical relevance when looking at antitumor drugs as well as the possible cause of Alzheimer's.
 =Dimers=