Sandbox Reserved 200: Difference between revisions

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[[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]]

Bovine pancreatic ribonuclease A (RNase A) is an enzyme that catalyzes the hydrolysis of RNA.  RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [[Proteopedia:Sandbox Reserved 192|monomer]].  The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >.  The 3D domain swapping has no impact on the formation of active sites.  These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer <ref name="liul"/>.     

<Structure load='1A2W' size='400' frame='true' align='right' caption='Ribonuclease A Dimer' scene='Sandbox_Reserved_200/Minor_dimer/2' />

<scene name='Sandbox_Reserved_200/Minor_dimer_hinge/1'>Ala19</scene>

<scene name='Sandbox_Reserved_200/Minor_dimer/2'>Minor dimer</scene>

<scene name='Sandbox_Reserved_200/Major_dimer/9'>N-terminus</scene>

<scene name='Sandbox_Reserved_200/Major_dimer/10'>C-terminus</scene>

<Structure load='1JS0' size='400' frame='true' align='left' caption='Ribonuclease A Minor Trimer' scene='Sandbox_Reserved_200/Minor Trimer/1' />

<references />