Sandbox Reserved 200: Difference between revisions
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[[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]] | [[Image:2D_RNase_A.png|200px|left|thumb|RNase A minor dimer,[[1A2W]]]] | ||
Bovine pancreatic ribonuclease A (RNase A) is an enzyme that catalyzes the hydrolysis of RNA. RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [[Proteopedia:Sandbox Reserved 192|monomer]]. The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >. The 3D domain swapping has no impact on the formation of active sites. These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer <ref name="liul"/>. | Bovine pancreatic ribonuclease A (RNase A) is an enzyme that catalyzes the hydrolysis of RNA. RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the [[Proteopedia:Sandbox Reserved 192|monomer]]. The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit <ref name="liul">PMID:11224563</ref >. The 3D domain swapping has no impact on the formation of active sites. These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer <ref name="liul"/>. | ||
<Structure load='1A2W' size='400' frame='true' align='right' caption='Ribonuclease A' scene='Sandbox_Reserved_200/Minor_dimer/2' /> | <Structure load='1A2W' size='400' frame='true' align='right' caption='Ribonuclease A Dimer' scene='Sandbox_Reserved_200/Minor_dimer/2' /> | ||
==Minor Dimer== | ==Minor Dimer== | ||
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==Trimers== | ==Trimers== | ||
<Structure load='1JS0' size='400' frame='true' align='left' caption='Ribonuclease A Minor Trimer' scene='Sandbox_Reserved_200/Minor Trimer/1' /> | |||
==Medical Relevance== | ==Medical Relevance== | ||
Revision as of 06:13, 31 March 2011
| This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200. |
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Oligomers of Bovine Ribonuclease AOligomers of Bovine Ribonuclease A
IntroductionIntroduction
Bovine pancreatic ribonuclease A (RNase A) is an enzyme that catalyzes the hydrolysis of RNA. RNase A has the capability to structurally form dimers, trimers, and other oligomers based on the structure of the monomer. The oligomers are formed by 3D domain swapping, which can occur once or twice per monomeric unit [1]. The 3D domain swapping has no impact on the formation of active sites. These same active sites, which are composed of His 12, Lys 41, and His 119, can be found in the monomer, dimer, and trimer [1].
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Minor DimerMinor Dimer
Major DimerMajor Dimer
TrimersTrimers
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Medical RelevanceMedical Relevance
Literature CitedLiterature Cited
- ↑ 1.0 1.1 Liu Y, Gotte G, Libonati M, Eisenberg D. A domain-swapped RNase A dimer with implications for amyloid formation. Nat Struct Biol. 2001 Mar;8(3):211-4. PMID:11224563 doi:10.1038/84941