Sandbox Reserved 339: Difference between revisions
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Information on aldose reductase is also available at [http://en.wikipedia.org/wiki/Aldose_reductase Wikipedia] | Information on aldose reductase is also available at [http://en.wikipedia.org/wiki/Aldose_reductase Wikipedia] | ||
==Introduction== | ==Introduction== | ||
<scene name='Sandbox_Reserved_339/Default_scene/1'>Aldose reductase</scene> is an oxidoreductase/dehydrogenase enzyme.<ref name="wikipedia"> Wikipedia. Aldose Reductase. http://en.wikipedia.org/wiki/Aldose_reductase </ref> Aldose reductase can reduce the aldehyde group of aldoses, aliphatic, aromatic aldehydes and some keto groups from aromatic and aliphatic ketones to their corresponding alcohol products using NADPH as a cofactor.<ref name="Steuber"> PMID 17368668 </ref><ref name="review"> PMID 15094999 </ref> Aldose reductase is most well known in the first step of the polyol pathway of glucose metabolism.<ref name="Steuber"/><ref name="review"/> | <scene name='Sandbox_Reserved_339/Default_scene/1'>Aldose reductase</scene> is an oxidoreductase/dehydrogenase enzyme.<ref name="wikipedia"> Wikipedia. Aldose Reductase. http://en.wikipedia.org/wiki/Aldose_reductase </ref> Aldose reductase can reduce the aldehyde group of aldoses, aliphatic, aromatic aldehydes and some keto groups from aromatic and aliphatic ketones to their corresponding alcohol products using NADPH as a cofactor.<ref name="Steuber"> PMID 17368668 </ref><ref name="review"> PMID 15094999 </ref> Aldose reductase is most well known in the first step of the polyol pathway of glucose metabolism (Figure 1).<ref name="Steuber"/><ref name="review"/> | ||
[[Image:Polyol_pathway.jpg|left|400px|thumb|Figure 1. Polyol pathway of glucose metabolism. Adapted from Petrash JM. All in the family: aldose reductase and closely related aldo-keto reductases. Cell Mol Life Sci. 2004 Apr;61(7-8):737-49. PMID:15094999 doi:10.1007/s00018-003-3402-3]] | [[Image:Polyol_pathway.jpg|left|400px|thumb|Figure 1. Polyol pathway of glucose metabolism. Adapted from Petrash JM. All in the family: aldose reductase and closely related aldo-keto reductases. Cell Mol Life Sci. 2004 Apr;61(7-8):737-49. PMID:15094999 doi:10.1007/s00018-003-3402-3]] | ||