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== Prion Protein (2HH0) == | == Prion Protein (2HH0) == | ||
2HH0 is a prion protein that manifests in bovine(cattle) and can lead to degenerative central nervous system tissues. The word “prion” is derived from “protein + infection.” Prions were discovered in 1997 by Stanley B. Prusiner of the University of California. | 2HH0 is a prion protein that manifests in bovine(cattle) and can lead to degenerative central nervous system tissues. The word “prion” is derived from “protein + infection.” Prions were discovered in 1997 by Stanley B. Prusiner of the University of California. <ref name="Prusiner, S.">Prusiner, S. Autobiography. Retrieved March 25, 2011, from NobelPrize.org Web site:http//nobelprize.org/nobel_prizes/medicine/laureates/1997/prusiner-autobio.html They are infected proteins and may lay dormant for many years before they activate and cause damage to the brain and spinal cord. <ref name="Luginbuhl, B.">Luginbuhl, B., Kanyo, Z., Jones, R.M., Fletterick, R.J., Prusiner, S.B., Cohen, F.E., Williamson, R.A., Burton, D.R., & Pluckthun, A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. 2006. J.Mol.Biol. 2006 363:75-97.</ref> | ||