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	P16INK4a is an oncoprotein and known tumor suppressor when over-expressed within the cell-progression pathway of the retinoblastoma protein (pRB). It is a cyclin-dependent kinase inhibitor that will negatively effect proliferation of a natural cell cycle. <ref name="Ungureanu"> Ungureanu, Carmen, Socolov, Demetra, Anton, Gabriela, Miahailovici, Maria Sultana, and Teleman, S. Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical		P16INK4a is an oncoprotein and known tumor suppressor when over-expressed within the cell-progression pathway of the retinoblastoma protein (pRB). It is a cyclin-dependent kinase inhibitor that will negatively effect proliferation of a natural cell cycle. <ref name="Ungureanu"> Ungureanu, Carmen, Socolov, Demetra, Anton, Gabriela, Miahailovici, Maria Sultana, and Teleman, S. Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical
	lesions progression risk.Romanian Journal of Morphology and Embryology 2010, 51(3):497–503 </ref>.		lesions progression risk.Romanian Journal of Morphology and Embryology 2010, 51(3):497–503 </ref>. The effectiveness of the over-expression occurs between the G1 and S phases of the cell cycle, making it significantly important in the stability of proliferation vs. growth arrest of the cell during the cell cycle.