Sandbox Reserved 167: Difference between revisions
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P16INK4a is an oncoprotein and known tumor suppressor when over-expressed within the cell-progression pathway of the retinoblastoma protein (pRB). It is a cyclin-dependent kinase inhibitor that will negatively effect proliferation of a natural cell cycle. | P16INK4a is an oncoprotein and known tumor suppressor when over-expressed within the cell-progression pathway of the retinoblastoma protein (pRB). It is a cyclin-dependent kinase inhibitor that will negatively effect proliferation of a natural cell cycle. <ref name="Tainer"> Ungureanu, Carmen, Socolov, Demetra, Anton, Gabriela, Miahailovici, Maria Sultana, and Teleman, S. Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical | ||
lesions progression risk.Romanian Journal of Morphology and Embryology 2010, 51(3):497–503 </ref>. | |||
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== Role In Cervical Cancer == | == Role In Cervical Cancer == | ||
P16INK4a is an important biomarker for high-risk Human Papillomavirus(HR-HPV)because it inhibits the phosphorylating activity associated with the cdk4/6 - cyclin D complex and the counterparts, retinoblastoma protein (pRB) and the transciption factor E2F. Progression of the cell cycle is controlled by the pRB pathway and its ability to bind to the transciption factor E2F to block the transcription of genes that promote cell proliferation. The pRB pathway is critical for the maintenance of balance between cell cycle continuous and cell cycle rest. <ref name="Tainer"> | P16INK4a is an important biomarker for high-risk Human Papillomavirus(HR-HPV)because it inhibits the phosphorylating activity associated with the cdk4/6 - cyclin D complex and the counterparts, retinoblastoma protein (pRB) and the transciption factor E2F. Progression of the cell cycle is controlled by the pRB pathway and its ability to bind to the transciption factor E2F to block the transcription of genes that promote cell proliferation. The pRB pathway is critical for the maintenance of balance between cell cycle continuous and cell cycle rest. <ref name="Tainer"> Silverman, Robert, RPh, MM and Ridder, Dr. Rüdiger. p16INK4a Antibody. MTM Laboratories Website. http://mtmlabs.com/us/index.php/science-a-technology/p16ink4a </ref>. | ||
== Structure of Protein == | == Structure of Protein == | ||