Sandbox Reserved 324: Difference between revisions
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{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
='''eIF2 (1q8k)'''= | ='''Human eIF2 (1q8k)'''= | ||
=Introduction= | =Introduction= | ||
The translation of proteins requires three steps to occur; initiation, elongation and termination. With each step one or more factors is involved in aiding the process. In eukaryotes initiation has the most factors that are essential for initiation to occur. eIF2 is one of the many initiating factors needed for eukaryotic initiation to occur. It is needed for proper initiation to occur. It initially binds to eIF2β with in the presence of GTP. It then binds to Met-tRNA<sup>meti</sup> and releases the eIF2β. This specific eIF2(1q8k) is the human eIF2 <ref>PMID:15341733</ref>. | The translation of proteins requires three steps to occur; initiation, elongation and termination. With each step one or more factors is involved in aiding the process. In eukaryotes initiation has the most factors that are essential for initiation to occur. eIF2 is one of the many initiating factors needed for eukaryotic initiation to occur. It is needed for proper initiation to occur. It initially binds to eIF2β with in the presence of GTP. It then binds to Met-tRNA<sup>meti</sup> and releases the eIF2β. This specific eIF2(1q8k) is the human eIF2 <ref>PMID:15341733</ref>. | ||
{{STRUCTURE_1q8k| PDB=1q8k | SCENE= }} | {{STRUCTURE_1q8k| PDB=1q8k | SCENE= }} | ||
=Structure= | |||
The human eIF2 structure was determined by NMR spectroscopy<ref>PMID:15341733</ref>. | |||
=Function= | |||
=References= | =References= | ||
<references/> | <references/> | ||
Revision as of 09:04, 28 March 2011
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
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Human eIF2 (1q8k)Human eIF2 (1q8k)
IntroductionIntroduction
The translation of proteins requires three steps to occur; initiation, elongation and termination. With each step one or more factors is involved in aiding the process. In eukaryotes initiation has the most factors that are essential for initiation to occur. eIF2 is one of the many initiating factors needed for eukaryotic initiation to occur. It is needed for proper initiation to occur. It initially binds to eIF2β with in the presence of GTP. It then binds to Met-tRNAmeti and releases the eIF2β. This specific eIF2(1q8k) is the human eIF2 [1].
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| 1q8k, 15 NMR models () | |||||||||
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| Gene: | EIF2S1 OR EIF2A (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
StructureStructure
The human eIF2 structure was determined by NMR spectroscopy[2].
FunctionFunction
ReferencesReferences
- ↑ Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010
- ↑ Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep;12(9):1693-704. PMID:15341733 doi:10.1016/j.str.2004.07.010