2hur: Difference between revisions
New page: left|200px<br /><applet load="2hur" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hur, resolution 1.62Å" /> '''Escherichia coli nuc... |
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[[Image:2hur.gif|left|200px]]<br /><applet load="2hur" size=" | [[Image:2hur.gif|left|200px]]<br /><applet load="2hur" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2hur, resolution 1.62Å" /> | caption="2hur, resolution 1.62Å" /> | ||
'''Escherichia coli nucleoside diphosphate kinase'''<br /> | '''Escherichia coli nucleoside diphosphate kinase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2HUR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] Full crystallographic information is available from [http:// | 2HUR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUR OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: type ii tetramer]] | [[Category: type ii tetramer]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:57:59 2008'' | ||
Revision as of 15:57, 23 January 2008
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Escherichia coli nucleoside diphosphate kinase
OverviewOverview
Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of, gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates., The subunit folding and the dimeric basic structural unit are remarkably, the same for available structures but, depending on species, dimers, self-associate to form hexamers or tetramers. The crystal structure of the, Escherichia coli NDPK reveals a new tetrameric quaternary structure for, this protein family. The two tetramers differ by the relative orientation, of interacting dimers, which face either the convex or the concave side of, their central sheet as in either Myxococcus xanthus (type I) or E. coli, (type II), respectively. In the type II tetramer, the subunits interact by, a new interface harboring a zone called the Kpn loop as in hexamers, but, by the opposite face of this loop. The evolutionary conservation of the, interface residues indicates that this new quaternary structure seems to, be the most frequent assembly mode in bacterial tetrameric NDP kinases., Proteins 2007. (c) 2007 Wiley-Liss, Inc.
About this StructureAbout this Structure
2HUR is a Single protein structure of sequence from Escherichia coli with as ligand. Active as Nucleoside-diphosphate kinase, with EC number 2.7.4.6 Full crystallographic information is available from OCA.
ReferenceReference
The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family., Moynie L, Giraud MF, Georgescauld F, Lascu I, Dautant A, Proteins. 2007 Feb 28;67(3):755-765. PMID:17330300
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