2nnq: Difference between revisions
New page: left|200px<br /> <applet load="2nnq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nnq, resolution 1.80Å" /> '''Crystal structure o... |
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid'''<br /> | '''Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2NNQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and T4B as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2NNQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=T4B:'>T4B</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNQ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:55:06 2008'' | ||
Revision as of 15:55, 23 January 2008
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Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid
OverviewOverview
Herein we report the first disclosure of biphenyl azoles that are, nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2), with up to thousand-fold selectivity against muscle fatty acid binding, protein and epidermal fatty acid binding protein. In addition a new, radio-ligand to determine binding against the three fatty acid binding, proteins was also synthesized.
About this StructureAbout this Structure
2NNQ is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)., Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL, Sheriff S, Adam LP, Ewing WR, Robl JA, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. Epub 2006 Dec 21. PMID:17502136
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