Sandbox Reserved 313: Difference between revisions
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{{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}} | {{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}} | ||
=Introduction= | =Introduction= | ||
'''Sphingomyelin phosphodiesterase (Sphingomyelinase)''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin signal transduction pathway which is involved in apoptosis. This pathway is initiated by sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586 </ref>. There are 6 known types of sphingomyelinases<ref name="gp3">PMID: 12401200 </ref>. : | '''Sphingomyelin phosphodiesterase (Sphingomyelinase):''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin signal transduction pathway which is involved in apoptosis. This pathway is initiated by sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586 </ref>. There are 6 known types of sphingomyelinases<ref name="gp3">PMID: 12401200 </ref>. : | ||
''Acid sphingomyelinase (aSMase)'' - | ''Acid sphingomyelinase (aSMase)'' - | ||