2eb9: Difference between revisions
New page: left|200px<br /><applet load="2eb9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eb9, resolution 1.80Å" /> '''Crystal Structure of... |
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'''Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin'''<br /> | '''Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2EB9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with PO4, CUS and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2EB9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CUS:'>CUS</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB9 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxygen storage/transport]] | [[Category: oxygen storage/transport]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:39:13 2008'' | ||
Revision as of 15:39, 23 January 2008
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Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin
OverviewOverview
apo-Myoglobin (apo-Mb) was reconstituted with three copper complexes:, CuII(Sal-Phe) (1; Sal-Phe = N-salicylidene-l-phenylalanato), CuII(Sal-Leu), (2; Sal-Leu = N-salicylidene-l-leucinato), and CuII(Sal-Ala) (3; Sal-Ala =, N-salicylidene-l-alanato). The crystal structures of 1.apo-Mb (1.65 A, resolution) and 2.apo-Mb (1.8 A resolution) show that the coordination, geometry around the CuII atom in apo-Mb is distorted square-planar with, tridentate Sal-X and a Nepsilon atom of His64 in the apo-Mb cavity and the, plane of these copper complexes is perpendicular to that of heme. These, results suggest that the apo-Mb cavity can hold metal complexes with, various coordination geometries.
About this StructureAbout this Structure
2EB9 is a Single protein structure of sequence from Physeter catodon with , and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Design and Structure Analysis of Artificial Metalloproteins: Selective Coordination of His64 to Copper Complexes with Square-Planar Structure in the apo-Myoglobin Scaffold., Abe S, Ueno T, Reddy PA, Okazaki S, Hikage T, Suzuki A, Yamane T, Nakajima H, Watanabe Y, Inorg Chem. 2007 Jun 25;46(13):5137-5139. Epub 2007 May 25. PMID:17523632
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