1zvx: Difference between revisions
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[[Image:1zvx.png|left|200px]] | [[Image:1zvx.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
[[1zvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVX OCA]. | |||
==Reference== | ==Reference== | ||
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[[Category: Stereoselective inhibition]] | [[Category: Stereoselective inhibition]] | ||
[[Category: Sulfonamide junction]] | [[Category: Sulfonamide junction]] | ||
Revision as of 22:55, 14 March 2011
Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)
Template:ABSTRACT PUBMED 16451058
About this StructureAbout this Structure
1zvx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4]
- ↑ Pochetti G, Gavuzzo E, Campestre C, Agamennone M, Tortorella P, Consalvi V, Gallina C, Hiller O, Tschesche H, Tucker PA, Mazza F. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem. 2006 Feb 9;49(3):923-31. PMID:16451058 doi:10.1021/jm050787+
- ↑ Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci. 1999 Jul;8(7):1455-62. PMID:10422833
- ↑ Gavuzzo E, Pochetti G, Mazza F, Gallina C, Gorini B, D'Alessio S, Pieper M, Tschesche H, Tucker PA. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J Med Chem. 2000 Sep 7;43(18):3377-85. PMID:10978185
- ↑ Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:7737183