3dy7: Difference between revisions
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Revision as of 22:24, 14 March 2011
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATPX-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Template:ABSTRACT PUBMED 19019675
About this StructureAbout this Structure
3dy7 is a 1 chain structure of Mitogen-activated protein kinase kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. Epub 2008 Oct 31. PMID:19019675 doi:10.1016/j.bmcl.2008.10.108
- ↑ Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157 doi:10.1038/nsmb859
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Mitogen-activated protein kinase kinase
- Ohren, J F.
- Pavlovsky, A.
- Zhang, E.
- Acetylation
- Atp-binding
- Atp-bound protein kinase
- Disease mutation
- Dual specificity protein kinase
- Inhibitor-bound protein kinase
- Non-atp-competitive kinase inhibitor
- Nucleotide-binding
- Phosphoprotein
- Serine/threonine-protein kinase
- Transferase
- Tyrosine-protein kinase