1h3b: Difference between revisions
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[[Image:1h3b.png|left|200px]] | [[Image:1h3b.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
[[1h3b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3B OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:12747780</ref><references group="xtra"/> | <ref group="xtra">PMID:12747780</ref><ref group="xtra">PMID:12031670</ref><ref group="xtra">PMID:9931258</ref><ref group="xtra">PMID:9295270</ref><ref group="xtra">PMID:9162756</ref><references group="xtra"/> | ||
[[Category: Alicyclobacillus acidocaldarius]] | [[Category: Alicyclobacillus acidocaldarius]] | ||
[[Category: Aebi, J D.]] | [[Category: Aebi, J D.]] | ||
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[[Category: Monotopic membrane protein]] | [[Category: Monotopic membrane protein]] | ||
[[Category: Oxidosqualene cyclase]] | [[Category: Oxidosqualene cyclase]] | ||
Revision as of 22:16, 14 March 2011
SQUALENE-HOPENE CYCLASESQUALENE-HOPENE CYCLASE
Template:ABSTRACT PUBMED 12747780
About this StructureAbout this Structure
1h3b is a 3 chain structure with sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4][xtra 5]
- ↑ Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE. Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem. 2003 May 22;46(11):2083-92. PMID:12747780 doi:http://dx.doi.org/10.1021/jm0211218
- ↑ Lenhart A, Weihofen WA, Pleschke AE, Schulz GE. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem Biol. 2002 May;9(5):639-45. PMID:12031670
- ↑ Wendt KU, Lenhart A, Schulz GE. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J Mol Biol. 1999 Feb 12;286(1):175-87. PMID:9931258 doi:http://dx.doi.org/10.1006/jmbi.1998.2470
- ↑ Wendt KU, Poralla K, Schulz GE. Structure and function of a squalene cyclase. Science. 1997 Sep 19;277(5333):1811-5. PMID:9295270
- ↑ Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. PMID:9162756