Simvastatin Synthase: Difference between revisions
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{{STRUCTURE_3hle | PDB=3hle | SCENE= }} | {{STRUCTURE_3hle | PDB=3hle | SCENE= }} | ||
==Introduction== | ==Introduction== | ||
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | '''Simvastation synthase''' (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | ||
Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) | Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) by dimethylbutyryl chloride to yield the protected form of simvastatin, which is subsequently deprotected to yield simvastatin | ||
[[Image:LovD copy.jpg]] | |||
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | ||