Simvastatin Synthase: Difference between revisions

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+==Simvastatin Synthase==
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 Simvastatin Synthase, LovD, is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin. LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.