Naproxen: Difference between revisions
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'''Cyclooxygenase''' abbreviated as '''COX''' is an enzyme that is responsible for the production of prostanoids, such as prostaglandins, prostacyclin and thromboxane. These eicosanoids, or more simply signaling molecules, are responsible for inflammatory and anaphylactic reactions, vasoconstriction, and the resolution of inflammation respectively. Inhibition of this enzyme can therefore lead to temporary relief of pain and inflammation. | '''Cyclooxygenase''' abbreviated as '''COX''' is an enzyme that is responsible for the production of prostanoids, such as prostaglandins, prostacyclin and thromboxane. These eicosanoids, or more simply signaling molecules, are responsible for inflammatory and anaphylactic reactions, vasoconstriction, and the resolution of inflammation respectively. Inhibition of this enzyme can therefore lead to temporary relief of pain and inflammation. | ||
Nonsteroidal anti-inflammatory drugs, NSAID, target and inhibit the COX enzyme to achieve these desired effects. Of the three variants, (COX-1, COX-2, COX-3), Naproxen targets COX-1 and COX-2. | Nonsteroidal anti-inflammatory drugs, NSAID, target and inhibit the COX enzyme to achieve these desired effects. Of the three variants, (COX-1, COX-2, COX-3), Naproxen targets COX-1 and COX-2, both of which are found in the blood, kidneys, and stomach. COX-1 is an essential enzyme in the bioshynthesis of prostaglandin responsible for the inflammatory and anaphylactic reations. But COX-1 is also involved in the synthesis of the natural mucus lining that protects the stomach, hence why an overdose, or frequent doses can cause stomach ulcers and bleeding. | ||
==Naproxen In Vivo== | ==Naproxen In Vivo== | ||