2p01: Difference between revisions
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'''The structure of receptor-associated protein(RAP)'''<br /> | '''The structure of receptor-associated protein(RAP)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2P01 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2P01 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P01 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: receptor-associated protein]] | [[Category: receptor-associated protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:02:43 2008'' | ||
Revision as of 15:02, 23 January 2008
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The structure of receptor-associated protein(RAP)
OverviewOverview
The receptor-associated protein (RAP) is a molecular chaperone that binds, tightly to certain newly synthesized LDL receptor family members in the, endoplasmic reticulum (ER) and facilitates their delivery to the Golgi. We, have adopted a divide-and-conquer strategy to solve the structures of the, individual domains of RAP using NMR spectroscopy. We present here the, newly determined structure of domain 2. Based on this structure and the, structures of domains 1 and 3, which were solved previously, we utilized, experimental small-angle neutron scattering (SANS) data and a novel, simulated annealing protocol to characterize the overall structure of RAP., The results reveal that RAP adopts a unique structural architecture, consisting of three independent three-helix bundles that are connected by, long and flexible linkers. The flexible linkers and the quasi-repetitive, structural architecture may allow RAP to adopt various possible, conformations when interacting with the LDL receptors, which are also made, of repetitive substructure units.
About this StructureAbout this Structure
2P01 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structure of receptor-associated protein (RAP)., Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DK, Wang YX, Protein Sci. 2007 Aug;16(8):1628-40. PMID:17656581
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