2nv7: Difference between revisions

Revision as of 15:01, 23 January 2008

Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555

OverviewOverview

A series of 4'-hydroxyphenyl-aryl-carbaldehyde oximes (5b) was prepared, and found to have high affinity (4nM) and modest selectivity (39-fold) for, estrogen receptor-beta (ERbeta). Substitution of one of the core rings of, the scaffold based around these novel ligands further expanded our, knowledge in the quest toward achieving high affinity and selectivity for, ERbeta. An X-ray co-crystal of structure 11 revealed that the oxime moiety, was mimicking the C-ring of genistein, as previously predicted by SAR and, docking studies.

About this StructureAbout this Structure

2NV7 is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Histone acetyltransferase, with EC number 2.3.1.48 Full crystallographic information is available from OCA.

ReferenceReference

ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives., Mewshaw RE, Bowen SM, Harris HA, Xu ZB, Manas ES, Cohn ST, Bioorg Med Chem Lett. 2007 Feb 15;17(4):902-6. Epub 2006 Dec 1. PMID:17188490

Page seeded by OCA on Wed Jan 23 14:01:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2nv7.gif|left|200px]]<br />
+[[Image:2nv7.jpg|left|200px]]<br /><applet load="2nv7" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2nv7" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2nv7, resolution 2.10&Aring;" />
 '''Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555'''<br />
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 ==About this Structure==
-NV7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 555 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NV7 OCA].
+NV7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=555:'>555</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NV7 OCA].
 ==Reference==
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 [[Category: transcription factor]]
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