Interleukin-15/Sandbox: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
(General Description) | (General Description) | ||
Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases. | |||
Revision as of 00:18, 2 March 2011
(General Description) Interleukin-15 (IL-15) is a 14-15kDa cytokine with similar biological functions to IL-2 (Kirman, 1998), eliciting such responses as differentiation and proliferation of lymphocytes, expression of cytolytic programs in lymphocytic killer cells, and chemoattraction of T cells (Chae, 1996). IL-15 has also been implicated in homeostatic proliferaton and deemed necessary for CD8+ T cell memory. In high enough concentrations, IL-15 has been implicated in chronic inflammatory diseases.
Structure & FunctionStructure & Function
StructureStructure
(Structural Description) (highlighting domains, folds and/or motifs) This is a placeholder text to help you get started in placing a Jmol applet on your page. At any time, click "Show Preview" at the bottom of this page to see how it goes.
Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.
| |||||||||
| 3cin, resolution 1.70Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||||
| Gene: | TM1419, TM_1419 (Thermotoga maritima MSB8) | ||||||||
| Activity: | Inositol-3-phosphate synthase, with EC number 5.5.1.4 | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
FunctionFunction
(Structural insights into its function)
DiseaseDisease
Evolutionarily Related ProteinsEvolutionarily Related Proteins
Proteins + (Links to evolutionarily related proteins) example IL-2, IL-7
Solved StructuresSolved Structures
(Links to available structures) 2PSM 2Z3Q 2Z3R 2ERS