1gow: Difference between revisions
New page: left|200px<br /> <applet load="1gow" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gow, resolution 2.6Å" /> '''BETA-GLYCOSIDASE FRO... |
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==About this Structure== | ==About this Structure== | ||
1GOW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GOW OCA]]. | 1GOW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]]. Active as [[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23]]. Structure known Active Sites: CTA and CTB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GOW OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability., Aguilar CF, Sanderson I, Moracci M, Ciaramella M, Nucci R, Rossi M, Pearl LH, J Mol Biol. 1997 Sep 5;271(5):789-802. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9299327 9299327] | Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability., Aguilar CF, Sanderson I, Moracci M, Ciaramella M, Nucci R, Rossi M, Pearl LH, J Mol Biol. 1997 Sep 5;271(5):789-802. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9299327 9299327] | ||
[[Category: Beta-galactosidase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 12:32, 30 October 2007
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BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS
OverviewOverview
Enzymes from hyperthermophilic organisms must operate at temperatures, which rapidly denature proteins from mesophiles. The structural basis of, this thermostability is still poorly understood. Towards a further, understanding of hyperthermostability, we have determined the crystal, structure of the beta-glycosidase (clan GH-1A, family 1) from the, hyperthermophilic archaeon Sulfolobus solfataricus at 2.6 A resolution., The enzyme is a tetramer with subunit molecular mass at 60 kDa, and, crystallises with half of the tetramer in the asymmetric unit. The, structure is a (betaalpha)8 barrel, but with substantial elaborations, between the beta-strands and alpha-helices in each repeat. The active site, occurs at the centre of the top face of the barrel and is connected to the, surface by a ... [(full description)]
About this StructureAbout this Structure
1GOW is a [Single protein] structure of sequence from [Sulfolobus solfataricus]. Active as [Beta-galactosidase], with EC number [3.2.1.23]. Structure known Active Sites: CTA and CTB. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability., Aguilar CF, Sanderson I, Moracci M, Ciaramella M, Nucci R, Rossi M, Pearl LH, J Mol Biol. 1997 Sep 5;271(5):789-802. PMID:9299327
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