3me6: Difference between revisions
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===Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel=== | ===Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel=== | ||
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(as it appears on PubMed at http://www.pubmed.gov), where 20815363 is the PubMed ID number. | |||
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{{ABSTRACT_PUBMED_20815363}} | |||
==About this Structure== | ==About this Structure== | ||
[[3me6]] is a 4 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME6 OCA]. | |||
==See Also== | |||
*[[Cytochrome P450]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:16373351</ref><ref group="xtra">PMID:15100217</ref><ref group="xtra">PMID:14563924</ref><ref group="xtra">PMID:17887776</ref><ref group="xtra">PMID:19397311</ref><references group="xtra"/> | <ref group="xtra">PMID:20815363</ref><ref group="xtra">PMID:16373351</ref><ref group="xtra">PMID:15100217</ref><ref group="xtra">PMID:14563924</ref><ref group="xtra">PMID:17887776</ref><ref group="xtra">PMID:19397311</ref><references group="xtra"/> | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Unspecific monooxygenase]] | [[Category: Unspecific monooxygenase]] | ||
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[[Category: Talakad, J C.]] | [[Category: Talakad, J C.]] | ||
[[Category: Zhang, Q.]] | [[Category: Zhang, Q.]] | ||
Revision as of 08:03, 16 February 2011
Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrelCrystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel
Template:ABSTRACT PUBMED 20815363
About this StructureAbout this Structure
3me6 is a 4 chain structure of Cytochrome P450 with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4][xtra 5][xtra 6]
- ↑ Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 2010 Oct 12;49(40):8709-20. Epub 2010 Sep 15. PMID:20815363 doi:10.1021/bi100914z
- ↑ Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem. 2006 Mar 3;281(9):5973-81. Epub 2005 Dec 21. PMID:16373351 doi:10.1074/jbc.M511464200
- ↑ Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem. 2004 Jun 25;279(26):27294-301. Epub 2004 Apr 20. PMID:15100217 doi:10.1074/jbc.M403349200
- ↑ Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201. Epub 2003 Oct 16. PMID:14563924 doi:http://dx.doi.org/10.1073/pnas.2133986100
- ↑ Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 2007 Oct 16;46(41):11559-67. Epub 2007 Sep 22. PMID:17887776 doi:http://dx.doi.org/10.1021/bi7011614
- ↑ Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1Himidazole: ligand induced structural response through -helical repositioning. Biochemistry. 2009 Apr 27. PMID:19397311 doi:10.1021/bi9003765