Colicin E7: Difference between revisions
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==Killing Activities== | ==Killing Activities== | ||
{{STRUCTURE_1zns | PDB= | {{STRUCTURE_1zns | PDB=1zns | SCENE= }} | ||
Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows the domain in complex with DNA. | Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows the domain in complex with DNA. | ||
Revision as of 17:41, 31 January 2011
Colicin E3 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its DNase activity; it digests the cell's genome in specific locations, ultimately leading to the death of the cell.
Synthesis and releaseSynthesis and release
After synthesis inside the E. coli cell, the colicin binds its immunity protein, Im7, to its nuclease domain, to prevent the host cell from being killed by its activity. This immunity protein is released only on binding to the outer membrane of the target cell.
Mechanism of uptakeMechanism of uptake
Killing ActivitiesKilling Activities
Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows the domain in complex with DNA.