1hi5: Difference between revisions
New page: left|200px<br /> <applet load="1hi5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hi5, resolution 1.80Å" /> '''EOSINOPHIL-DERIVED ... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1HI5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HI5 OCA]]. | 1HI5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: ADP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HI5 OCA]]. | ||
==Reference== | ==Reference== | ||
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors., Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR, J Biol Chem. 2001 May 4;276(18):15009-17. Epub 2001 Jan 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11154698 11154698] | Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors., Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR, J Biol Chem. 2001 May 4;276(18):15009-17. Epub 2001 Jan 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11154698 11154698] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Pancreatic ribonuclease]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
| Line 28: | Line 29: | ||
[[Category: rnase-2]] | [[Category: rnase-2]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:31:16 2007'' | ||
Revision as of 12:26, 30 October 2007
|
EOSINOPHIL-DERIVED NEUROTOXIN (EDN)-ADENOSINE-5'-DIPHOSPHATE COMPLEX
OverviewOverview
Eosinophil-derived neurotoxin (EDN), a basic ribonuclease found in the, large specific granules of eosinophils, belongs to the pancreatic RNase A, family. Although its physiological function is still unclear, it has been, shown that EDN is a neurotoxin capable of inducing the Gordon phenomenon, in rabbits. EDN is also a potent helminthotoxin and can mediate antiviral, activity of eosinophils against isolated virions of the respiratory, syncytial virus. EDN is a catalytically efficient RNase sharing similar, substrate specificity with pancreatic RNase A with its ribonucleolytic, activity being absolutely essential for its neurotoxic, helminthotoxic, and antiviral activities. The crystal structure of recombinant human EDN, in the unliganded form has been determined previously (Mosimann, S. ... [(full description)]
About this StructureAbout this Structure
1HI5 is a [Single protein] structure of sequence from [Homo sapiens] with ADP as [ligand]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: ADP. Full crystallographic information is available from [OCA].
ReferenceReference
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors., Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR, J Biol Chem. 2001 May 4;276(18):15009-17. Epub 2001 Jan 11. PMID:11154698
Page seeded by OCA on Tue Oct 30 11:31:16 2007