Actin: Difference between revisions
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{{STRUCTURE_3hbt| PDB=3hbt | SIZE=300| SCENE=Actin/Cv/1 |right|CAPTION=Native G-actin [[3hbt]] }} | {{STRUCTURE_3hbt| PDB=3hbt | SIZE=300| SCENE=Actin/Cv/1 |right|CAPTION=Native G-actin [[3hbt]] }} | ||
[[Actin]] is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: | [[Actin]] is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: α (Aa) (or G-actin) found in muscle tissue, β (Ab) and γ (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, ''i.e.'' the crystal structure of rabbit Native G-actin ([[3hbt]]). | ||
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=== | === α actin 1 (Aa) === | ||
[[2w49]] – cAa +troponin C+ troponin T+ troponin I+ tropomyocin alpha-1 – chicken<br /> | [[2w49]] – cAa +troponin C+ troponin T+ troponin I+ tropomyocin alpha-1 – chicken<br /> | ||
[[1mdu]] – cAa+hGelsolin<br />[[3hbt]], [[2zwh]], [[1nwk]], [[1j6z]] – rAa – rabbit<br /> | [[1mdu]] – cAa+hGelsolin<br /> | ||
[[3hbt]], [[2zwh]], [[1nwk]], [[1j6z]], [[3g37]] – rAa – rabbit<br /> | |||
[[2q1n]], [[2q31]], [[2a5x]], [[1rdw]], [[1rfq]], [[1lcu]] – rAa – dimer<br /> | [[2q1n]], [[2q31]], [[2a5x]], [[1rdw]], [[1rfq]], [[1lcu]] – rAa – dimer<br /> | ||
[[3mfp]] – rAa – Cryo EM<br /> | |||
[[2q36]], [[1qz5]] – rAa+kabiramide C – dimer<br /> | [[2q36]], [[1qz5]] – rAa+kabiramide C – dimer<br /> | ||
[[2hmp]] – rAa – protease cleaved<br /> | [[2hmp]] – rAa – protease cleaved<br /> | ||
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[[1y64]] – rAa+yBNI1 domain FH2 - yeast<br /> | [[1y64]] – rAa+yBNI1 domain FH2 - yeast<br /> | ||
[[1sqk]] – rAa+DmCiboulot - ''Drosophila melanogaster'' (Dm)<br /> | [[1sqk]] – rAa+DmCiboulot - ''Drosophila melanogaster'' (Dm)<br /> | ||
[[3mn5]] – rAa+ DmSpire WH2 domain<br /> | |||
[[2ff6]] - rAa+DmCiboulot+hGelsolin <br /> | [[2ff6]] - rAa+DmCiboulot+hGelsolin <br /> | ||
[[1s22]] – rAa+ulapualide A<br /> | [[1s22]] – rAa+ulapualide A<br /> | ||
[[1qz6]] – rAa+jaspisamide A<br /> | [[1qz6]] – rAa+jaspisamide A<br /> | ||
[[1lot]], [[1kxp]], [[1ma9]] – rAa+hVitamin D binding protein | [[1lot]], [[1kxp]], [[1ma9]] – rAa+hVitamin D binding protein | ||
[[3m1f]] – rAa+VOPL WH2 domain<br /> | |||
[[3m3n]] – rAa+mN-WASP<br /> | |||
[[3m6g]] – rAa+lobophorolide<br /> | |||
=== β actin (Ab) === | |||
=== | |||
[[3lue]] – hAb+hAlpha-actinin <br /> | [[3lue]] – hAb+hAlpha-actinin <br /> | ||
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=== | === γ 1 actin (Ag) === | ||
[[1atn]] – rAg+cDNase I<br /> | [[1atn]] – rAg+cDNase I<br /> | ||
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[[1yvn]] – yA (mutant)+hGelsolin <br /> | [[1yvn]] – yA (mutant)+hGelsolin <br /> | ||
[[1yag]] - yA+hGelsolin<br /> | [[1yag]] - yA+hGelsolin<br /> | ||
[[3mmv]] – DmA-5C+spire WH2 domain<br /> | |||
[[3mn6]], [[3mn7]], [[3mn9]] - DmA-5C (mutant)+spire<br /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||