1z6j: Difference between revisions
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{{ABSTRACT_PUBMED_15913999}} | {{ABSTRACT_PUBMED_15913999}} | ||
==About this Structure== | ==About this Structure== | ||
[[1z6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA]. | |||
==Reference== | ==Reference== | ||
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[[Category: Enzyme inhibitor complex]] | [[Category: Enzyme inhibitor complex]] | ||
[[Category: Gla]] | [[Category: Gla]] | ||
[[Category: Hydrolase]] | |||
[[Category: Pyrazinone]] | [[Category: Pyrazinone]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Thrombosis]] | [[Category: Thrombosis]] | ||
[[Category: Tissue factor]] | [[Category: Tissue factor]] | ||
Revision as of 20:47, 29 December 2010
Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone InhibitorCrystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
Template:ABSTRACT PUBMED 15913999
About this StructureAbout this Structure
1z6j is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:15913999 doi:10.1016/j.bmcl.2005.04.037
- ↑ South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:12824026
- ↑ Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:12954057 doi:http://dx.doi.org/10.1021/jm030130t
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Coagulation factor VIIa
- Homo sapiens
- Kurumbail, R G.
- Kusturin, C L.
- Neumann, W L.
- Poda, G I.
- Rahman, H K.
- Sample, K R.
- Schweitzer, B A.
- Stallings, W C.
- Stegeman, R A.
- Stevens, A M.
- Benzamidine
- Blood coagulation
- Cofactor
- Enzyme inhibitor complex
- Gla
- Hydrolase
- Pyrazinone
- Serine protease
- Thrombosis
- Tissue factor