Spectrin

File:3lbx.png

Crystal Structure of Spectrin 3lbx

Spectrin forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, i.e. the crystal structure of human Spectrin (3lbx).

3D Structures of Spectrin3D Structures of Spectrin

SPTA1SPTA1

3lbx – hSPTA1+hSPTB1 – human
3i9q, 2rot, 2pqh, 2oaw, 2nuz, 1u06 - cSPTA1 SH3 domain – chicken
2jm8, 2jm9, 2cdt, 2f2v, 2f2w, 2f2x - cSPTA1 SH3 domain (mutant)
2jma, 2jmc - cSPTA1 SH3 domain (mutant)+P41 peptide
2rmo, 1neg, 1m8m - cSPTA1 SH3 domain – NMR

SPTA2SPTA2

3f31 – hSPTA2 tetramerization domain
1qkw – cSPTA2 SH3 domain (mutant)
2fot - SPTA2+calmodulin – Bos taurus
3fb2 – hSPTA2 repeats 15-16

SPTASPTA

1uue, 1e7o, 1g2b, 1aey, 1tuc, 1tud - cSPTA SH3 domain (mutant) – NMR
1e6g, 1e6h, 1hd3, 1qkx, 1pwt, 1bk2, 1shg - cSPTA SH3 domain (mutant)
1u4q – cSPTA repeats 15-17
1u5p - cSPTA repeats 15-16
1cun - cSPTA repeats 16-17
1aj3 - cSPTA repeat 16 - NMR
1owa - hSPTA tetramerization domain – NMR
1h8k, 3ngp – cSPTA SH3 domain (mutant)
2kr3 - cSPTA SH3 domain

SPTB1SPTB1

3bkt, 3kbu - hSPTB1+ankyrin
3f57, 3edu - hSPTB1 ankyrin binding domain
1s35 – hSPTB1 repeats 8-9

SPTB2SPTB2

3edv – hSPTB2 repeats 14-16

SPTB3SPTB3

1wyq – hSPTB3 CH domain – NMR
1wjm – hSPTB3 – NMR

SPTBSPTB

1bkr, 1aa2 – hSPTB CH domain
1mph – SPTB Pleckstrin Homology domain – NMR
1dro - mSPTB PH domain – NMR – mouse
1btn – mSPTB+inositol phosphate
2spc – SPT fragment - Drosophila