1uuv: Difference between revisions
New page: left|200px<br /> <applet load="1uuv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uuv, resolution 1.65Å" /> '''NAPHTHALENE 1,2-DIO... |
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==About this Structure== | ==About this Structure== | ||
1UUV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]] with FE, SO4, FES, EDO, IND and NO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.12 1.14.12.12]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUV OCA]]. | 1UUV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]] with FE, SO4, FES, EDO, IND and NO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Naphthalene_1,2-dioxygenase Naphthalene 1,2-dioxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.12 1.14.12.12]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUV OCA]]. | ||
==Reference== | ==Reference== | ||
NO binding to naphthalene dioxygenase., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, J Biol Inorg Chem. 2005 Aug;10(5):483-9. Epub 2005 Sep 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15942729 15942729] | NO binding to naphthalene dioxygenase., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, J Biol Inorg Chem. 2005 Aug;10(5):483-9. Epub 2005 Sep 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15942729 15942729] | ||
[[Category: Naphthalene 1,2-dioxygenase]] | |||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pseudomonas putida]] | [[Category: Pseudomonas putida]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:24:17 2007'' | ||
Revision as of 12:19, 30 October 2007
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NAPHTHALENE 1,2-DIOXYGENASE WITH NITRIC OXIDE AND INDOLE BOUND IN THE ACTIVE SITE.
OverviewOverview
Nitric oxide (NO) is commonly used as an analogue for dioxygen in, structural and spectroscopic studies of oxygen binding and oxygen, activation. In this study, crystallographic structures of naphthalene, dioxygenase (NDO) in complex with nitric oxide are reported. In the, presence of the aromatic substrate indole, NO is bound end-on to the, active-site mononuclear iron of NDO. The structural observations correlate, well with spectroscopic measurements of NO binding to NDO in solution., However, the end-on binding of NO is in contrast to the recently reported, structure of oxygen to the active-site iron of NDO that binds side-on., While NO is a good oxygen analogue with many similarities to O(2), the, different binding mode of NO to the active-site iron atom leads to, different ... [(full description)]
About this StructureAbout this Structure
1UUV is a [Protein complex] structure of sequences from [Pseudomonas putida] with FE, SO4, FES, EDO, IND and NO as [ligands]. Active as [Naphthalene 1,2-dioxygenase], with EC number [1.14.12.12]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
NO binding to naphthalene dioxygenase., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, J Biol Inorg Chem. 2005 Aug;10(5):483-9. Epub 2005 Sep 23. PMID:15942729
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