2o5k: Difference between revisions
New page: left|200px<br /> <applet load="2o5k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o5k, resolution 3.20Å" /> '''Crystal Structure o... |
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[[Image:2o5k. | [[Image:2o5k.jpg|left|200px]]<br /><applet load="2o5k" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="2o5k, resolution 3.20Å" /> | caption="2o5k, resolution 3.20Å" /> | ||
'''Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor'''<br /> | '''Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2O5K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HBM as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] Full crystallographic information is available from [http:// | 2O5K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=HBM:'>HBM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O5K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:43:02 2008'' | ||
Revision as of 13:43, 23 January 2008
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Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor
OverviewOverview
A hydroxy functional group was introduced as the hydrogen bond donor and, acceptor at the hinge region of protein kinase in order to develop novel, ATP-competitive inhibitors. Several derivatives of, 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen, synthase kinase-3beta with the help of ab initio calculations and a, docking study. Enzymatic assay and an X-ray complex study showed that, these designed compounds were highly potent ATP-competitive inhibitors.
About this StructureAbout this Structure
2O5K is a Single protein structure of sequence from Homo sapiens with as ligand. Active as [Tau_protein_kinase [Tau protein] kinase], with EC number 2.7.11.26 Full crystallographic information is available from OCA.
ReferenceReference
Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta., Shin D, Lee SC, Heo YS, Lee WY, Cho YS, Kim YE, Hyun YL, Cho JM, Lee YS, Ro S, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5686-9. Epub 2007 Aug 19. PMID:17764934 [[Category: [Tau protein] kinase]]
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