1uzv: Difference between revisions
New page: left|200px<br /> <applet load="1uzv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzv, resolution 1.00Å" /> '''HIGH AFFINITY FUCOS... |
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==About this Structure== | ==About this Structure== | ||
1UZV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with FUC, SO4 and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZV OCA]]. | 1UZV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with FUC, SO4 and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: C1A. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZV OCA]]. | ||
==Reference== | ==Reference== | ||
High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches., Mitchell EP, Sabin C, Snajdrova L, Pokorna M, Perret S, Gautier C, Hofr C, Gilboa-Garber N, Koca J, Wimmerova M, Imberty A, Proteins. 2005 Feb 15;58(3):735-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15573375 15573375] | High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches., Mitchell EP, Sabin C, Snajdrova L, Pokorna M, Perret S, Gautier C, Hofr C, Gilboa-Garber N, Koca J, Wimmerova M, Imberty A, Proteins. 2005 Feb 15;58(3):735-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15573375 15573375] | ||
[[Category: Pseudomonas aeruginosa]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Budova, M.]] | [[Category: Budova, M.]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
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Revision as of 12:17, 30 October 2007
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HIGH AFFINITY FUCOSE BINDING OF PSEUDOMONAS AERUGINOSA LECTIN II: 1.0 A CRYSTAL STRUCTURE OF THE COMPLEX
OverviewOverview
PA-IIL is a fucose-binding lectin from Pseudomonas aeruginosa that is, closely related to the virulence factors of the bacterium. Previous, structural studies have revealed a new carbohydrate-binding mode with, direct involvement of two calcium ions (Mitchell E, Houles C, Sudakevitz, D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A., Structural basis for selective recognition of oligosaccharides from cystic, fibrosis patients by the lectin PA-IIL of Pseudomonas aeruginosa. Nat, Struct Biol 2002;9:918-921). A combination of thermodynamic, structural, and computational methods has been used to study the basis of the high, affinity for the monosaccharide ligand. A titration microcalorimetry study, indicated that the high affinity is enthalpy driven. The crystal ... [(full description)]
About this StructureAbout this Structure
1UZV is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with FUC, SO4 and CA as [ligands]. Structure known Active Site: C1A. Full crystallographic information is available from [OCA].
ReferenceReference
High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches., Mitchell EP, Sabin C, Snajdrova L, Pokorna M, Perret S, Gautier C, Hofr C, Gilboa-Garber N, Koca J, Wimmerova M, Imberty A, Proteins. 2005 Feb 15;58(3):735-46. PMID:15573375
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