1uzk: Difference between revisions
New page: left|200px<br /> <applet load="1uzk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzk, resolution 1.35Å" /> '''INTEGRIN BINDING CB... |
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==About this Structure== | ==About this Structure== | ||
1UZK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZK OCA]]. | 1UZK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZK OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: tb domain]] | [[Category: tb domain]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:19:55 2007'' | ||
Revision as of 12:15, 30 October 2007
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INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, CA BOUND TO CBEGF23 DOMAIN ONLY
OverviewOverview
Human fibrillin-1, the major structural protein of extracellular matrix, (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal, growth factor-like (cbEGF) and 7 transforming growth factor beta binding, protein-like (TB) domains. Crystal structures reveal the integrin binding, cbEGF22-TB4-cbEGF23 fragment of human fibrillin-1 to be a, Ca(2+)-rigidified tetragonal pyramid. We suggest that other cbEGF-TB pairs, within the fibrillins may adopt a similar orientation to cbEGF22-TB4. In, addition, we have located a flexible RGD integrin binding loop within TB4., Modeling, cell attachment and spreading assays, immunocytochemistry, and, surface plasmon resonance indicate that cbEGF22 bound to TB4 is a, requirement for integrin activation and provide insight into the molecular, ... [(full description)]
About this StructureAbout this Structure
1UZK is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization., Lee SS, Knott V, Jovanovic J, Harlos K, Grimes JM, Choulier L, Mardon HJ, Stuart DI, Handford PA, Structure. 2004 Apr;12(4):717-29. PMID:15062093
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